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Tetrahydrocannabinolic acid : ウィキペディア英語版 | Tetrahydrocannabinolic acid
Tetrahydrocannabinolic acid (THCA, Δ9-THCA, 2-COOH-THC), is a biosynthetic precursor of tetrahydrocannabinol (THC), the active component of cannabis. When purified, it forms a powder which is unstable in the presence of acids, heat, oxygen, and/or light.〔(Δ9-Tetrahydrocannabinolic Acid (Δ9-THCA) @ Aphios.com )〕 THCA is found in variable quantities in fresh, undried cannabis, but is progressively decarboxylated to THC with drying, and especially under intense heating such as when cannabis is smoked. == Pharmacological effects == THCA does not have any known psychoactive effects on humans in its own right. It does have antiinflammatory, neuroprotective, antiemetic (anti-vomitting)〔()〕 and anti-prostate cancer effects. It inhibits COX-1 and COX-2 enzymes involved in inflammation in human colon cell cultures.〔 It has also been shown to decrease the amount of oxidative stress caused by impairment of mitochondria which is a major mechanism in neural degeneration in mouse mesencephalic cell cultures.〔
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